Low-Level Human Equivalent Gestational Lead Exposure Produces Sex-Specific Motor and Coordination Abnormalities and Late-Onset Obesity in Year-Old Mice

@inproceedings{Leasure2007LowLevelHE,
  title={Low-Level Human Equivalent Gestational Lead Exposure Produces Sex-Specific Motor and Coordination Abnormalities and Late-Onset Obesity in Year-Old Mice},
  author={J Leigh Leasure and Anand Giddabasappa and Shawntay Chaney and Jerry E. Johnson and Konstantinos Pothakos and Yuen Sum Lau and Donald A. Fox},
  booktitle={Environmental health perspectives},
  year={2007}
}
BACKGROUND Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational lead exposure (GLE) have received little attention. OBJECTIVES Our goals were to establish a murine model of human equivalent GLE and to determine dose-response effects on body weight, motor functions, and dopamine neurochemistry in year-old offspring. METHODS We exposed female C57BL/6 mice to water containing 0, 27 (low), 55 (moderate… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 70 REFERENCES

Gender differences in the disposition and toxicity of met

AJ Verlangieri
  • Environ Res
  • 2007

C 57 BL / 6 J mice exhibit reduced dopamine D 3 receptor - mediated locomotorinhibitory function relative to DBA / 2 J mice

LD Middaugh, CL Randall, JP Favara
  • Neuroscience
  • 2006

The impact of early childhood lead exposure on brain organization : a functional magnetic resonance imaging study of language function

HJ Zhu, JS Wang, +3 authors LD Middaugh
  • Pediatrics
  • 2006
VIEW 1 EXCERPT