Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness.

@article{Schmid2012LowLP,
  title={Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness.},
  author={Thomas Ernst Schmid and C Greubel and Volker Hable and Olga Zlobinskaya and Darek Michalski and Stefanie Girst and Christian Siebenwirth and Elmar Schmid and Michael M Molls and Gabriele Multhoff and Gavin Dollinger},
  journal={Physics in medicine and biology},
  year={2012},
  volume={57 19},
  pages={5889-907}
}
This study shows that enhanced radiobiological effectiveness (RBE) values can be generated focusing low linear energy transfer (LET) radiation and thus changing the microdose distribution. 20 MeV protons (LET = 2.65 keV µm(-1)) are focused to submicrometer diameter at the ion microprobe superconducting nanoprobe for applied nuclear (Kern) physics experiments of the Munich tandem accelerator. The RBE values, as determined by measuring micronuclei (RBE(MN) = 1.48 ± 0.07) and dicentrics (RBE(D… CONTINUE READING