Low K+-induced hyperpolarizations trigger transient depolarizations and action potentials in rabbit ventricular myocytes.

@article{AkuzawaTateyama1998LowKH,
  title={Low K+-induced hyperpolarizations trigger transient depolarizations and action potentials in rabbit ventricular myocytes.},
  author={Miyuki Akuzawa-Tateyama and Michihiro Tateyama and Rikuo Ochi},
  journal={The Journal of physiology},
  year={1998},
  volume={513 ( Pt 3)},
  pages={775-86}
}
1. The effects of large reductions of [K+]o on membrane potential were studied in isolated rabbit ventricular myocytes using the whole-cell patch clamp technique. 2. Decreasing [K+]o from the normal level of 5.4 mM to 0.1 mM increased resting membrane potential (Vrest) from -75.6 +/- 0.3 to -140.3 +/- 1.9 mV (means +/- s.e.m; n = 127), induced irregular, transient depolarizations with mean maximal amplitudes of 19.5 +/- 1.5 mV and elicited action potentials in 56.7 % of trials. The action… CONTINUE READING