Low Grade Ovarian Serous Carcinoma - A Clinical-Morphologic Study

  title={Low Grade Ovarian Serous Carcinoma - A Clinical-Morphologic Study},
  author={C. Dochiţ and A. Stepan and C. Mărgăritescu and R. Ciurea and C. Simionescu},
  journal={Current Health Sciences Journal},
  pages={42 - 46}
Low grade ovarian serous carcinomas (LGSC) are rare tumors, representing only a small part of all ovarian carcinomas. The study included six LGSC cases for which we followed the clinical-epidemiological and morphological parameters depending on the tumoral stages. The tumors corresponded to stage I in four cases, in one case to stage II and in another case to stage III. The majority of the analyzed histopathological parameters were present in all tumoral stages. The accuracy of the diagnostic… Expand


Morphological and molecular basis of ovarian serous carcinoma
This review focuses on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise: the low-grade and the high-grade pathways. Expand
Ovarian Low-grade Serous Carcinoma: A Clinicopathologic Study of 33 Cases With Primary Surgery Performed at a Single Institution
Ovarian low-grade serous carcinoma (LGSC) is an entity with distinct pathologic and clinical features and has a short-term survival advantage over patients with HGSC, but over a prolonged period of time, this survival advantage decreases. Expand
Ovarian Serous Tumors of Low Malignant Potential With Nodal Low-grade Serous Carcinoma
A case series of patients with ovarian SLMP who, despite any evidence of LGSC in the pelvis or any pelvic recurrences, developed extrapelvic/extra-abdominal nodal LGSC, suggesting that SLMP/LGSC tumors in lymph nodes may arise independently of the ovarian primary. Expand
Grading Ovarian Serous Carcinoma Using a Two-Tier System
There is usually a good correlation between the two-tier grading system herein presented and the Shimizu/Silverberg and the FIGO grading systems, and this system should provide better reproducibility in the grading of ovarian serous carcinoma. Expand
Low-grade Serous Carcinoma of the Ovary: Clinicopathologic Analysis of 52 Invasive Cases and Identification of a Possible Noninvasive Intermediate Lesion
The presence of intraluminal proliferations of cells resembling LGSC occurring in SBT should prompt additional tumor sampling and assiduous evaluation of implants (if present), as this appears to represent a form of intraepithelial carcinoma, which may be associated with invasion elsewhere. Expand
Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries.
Using a life-table technique for survival analysis, it was not possible to demonstrate a significant difference in survival rates in cases with and without psammoma bodies, although the histological type, tumor stage, and grade, all known to be of prognostic importance, are kept constant. Expand
Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic Problems
An update is provided on the pathogenesis and clinicopathologic features of these 2 types of serous carcinomas and addresses some of the diagnostic problems that are encountered in routine practice. Expand
Long‐term oncological outcomes of ovarian serous carcinomas with psammoma bodies: A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma
The results suggested that the formation of psammoma bodies is associated with increased apoptotic tumor cell death related to normal TP53 function, which might contribute to the consideration of pathogenesis and to the development of prognostic prediction rules for serous carcinomas. Expand
Ovarian low-grade serous carcinoma involving the cervix mimicking a cervical primary.
  • A. Malpica, M. Deavers
  • Medicine
  • International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2011
The histologic and immunohistochemical features and the in-situ hybridization results were in keeping with a diagnosis of metastatic ovarian low-grade serous carcinoma involving the cervix, and underscores the importance of attentive histopathologic examination and the use of ancillary tests to ensure the recognition of the site of origin of a neoplasm involvingThe cervix. Expand
Low-grade serous carcinoma of the ovary or peritoneum.
  • D. Gershenson
  • Medicine
  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2016
Preclinical studies have identified and elucidated genes and pathways-MAP kinase pathway, IGF1-R, the angiogenesis pathway, and possibly, the PI3K/AKT/mTOR pathway in low-grade serous carcinoma. Expand