Low Glutathione Peroxidase Activity Levels in Patients with Vitiligo

@article{Zedan2015LowGP,
  title={Low Glutathione Peroxidase Activity Levels in Patients with Vitiligo},
  author={Hatem Zedan and Amira A Abdel-Motaleb and Na Kassem and Heba Ahmed Abdel Hafeez and Mahmoud Rezk Abdelwahed Hussein},
  journal={Journal of Cutaneous Medicine and Surgery},
  year={2015},
  volume={19},
  pages={144 - 148}
}
Background Vitiligo is an idiopathic skin disease characterized by white areas on the skin due to loss of the functional melanocytes, with possible involvement of oxidative stress. Glutathione peroxidase (GPx) is an antioxidant enzyme that protects cells against oxidative damage. Aim To examine serum GPx levels in patients with vitiligo and to relate the findings to the clinical features. Patients and Methods The study group included 60 patients with vitiligo and 30 matching healthy controls… 
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TLDR
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OXIDATIVE STRESS, ANTI-MELANOCYTE AND ANTI TYROSINASE ANTIBODY IN VITILIGO AND RESPONSE TO TREATMENT
TLDR
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Pigmentation Traits, Sun Exposure, and Risk of Incident Vitiligo in Women.
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Gas flaring, a common practice in the oil and gas industry prevalent in the Niger Delta region of Nigeria, constitutes a major source of aerial pollutants with potential health effects. This study
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TLDR
This study found significantly higher levels of MDA and significantly lower levels of SOD, GPx, vitamins C and E and total antioxidant activity in vitiligo patients compared with controls.
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TLDR
It is demonstrated that antioxidant processes depletion (low TAS and low GPX activity) is clearly involved with vitiligo in Tunisian patients, regardless of the association of the disease with diabetes or dysthyroidism.
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TLDR
Examination of serum levels of malondialdehyde, selenium, vitamin E and A, and the erythrocyte activities of glutathione peroxidase, superoxide dismutase, and catalase revealed a significantly higher level in patients with active disease compared with the controls.
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TLDR
Significant increase in superoxide dismutase activity and lipid peroxidation levels in erythrocytes was observed in all age groups of vitiligo patients as compared with age-matched healthy controls, wherein an increase of 55% (P < 0.02) was observed.
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TLDR
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TLDR
Support of antioxidant system via nonenzymatic antioxidant compounds and antioxidant enzymes may be useful to prevent of melanocyte degeneration which occur due to oxidative damage in vitiligo.
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TLDR
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TLDR
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Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients
TLDR
The modification of membrane lipid components in vitiligo cells may be the biochemical basis for the mitochondrial impairment and the subsequent production of intracellular ROS following the exposure to a mild stress.
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