Low Focal Adhesion Signaling Promotes Ground State Pluripotency of Mouse Embryonic Stem Cells.

@article{Taleahmad2017LowFA,
  title={Low Focal Adhesion Signaling Promotes Ground State Pluripotency of Mouse Embryonic Stem Cells.},
  author={Sara Taleahmad and Mehdi Mirzaei and Azam Samadian and Seyedeh-Nafiseh Hassani and Paul A Haynes and Ghasem Hosseini Salekdeh and Hossein Baharvand},
  journal={Journal of proteome research},
  year={2017},
  volume={16 10},
  pages={3585-3595}
}
Mouse embryonic stem cells (mESCs) can be maintained in a pluripotent state when cultured with 2 inhibitors (2i) of extracellular signal-regulated kinase (MEK) and glycogen synthase kinase-3 (GSK3), and Royan 2 inhibitors (R2i) of FGF4 and TGFβ. The molecular mechanisms that control ESC self-renewal and pluripotency are more important for translating stem… CONTINUE READING
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