Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome.

@article{Baldus2007LowEA,
  title={Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome.},
  author={Claudia Dorothea Baldus and Peter Martus and Thomas Burmeister and Stefan Schwartz and Nicola Goekbuget and Clara D. Bloomfield and Dieter Hoelzer and Eckhard Thiel and Wolf Karsten Hofmann},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2007},
  volume={25 24},
  pages={3739-45}
}
PURPOSE Expression of the genes ERG (v-ets erythroblastosis virus E26 oncogene homolog) and BAALC (brain and acute leukemia, cytoplasmic) shows similarity during hematopoietic maturation and predicts outcome in acute myeloid leukemia. We hypothesized that like ERG, BAALC expression might be of prognostic significance in acute T-lymphoblastic leukemia (T-ALL) and that ERG and BAALC expression together would better identify the patient's risk profile. PATIENTS AND METHODS ERG and BAALC mRNA… CONTINUE READING

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