Low Doses of Gamma-Irradiation Induce an Early Bystander Effect in Zebrafish Cells Which Is Sufficient to Radioprotect Cells

@inproceedings{Pereira2014LowDO,
  title={Low Doses of Gamma-Irradiation Induce an Early Bystander Effect in Zebrafish Cells Which Is Sufficient to Radioprotect Cells},
  author={Sandrine Pereira and V{\'e}ronique Malard and J L Ravanat and A Davin and Jean Armengaud and Nicolas Foray and Christelle Adam-Guillermin},
  booktitle={PloS one},
  year={2014}
}
The term "bystander effect" is used to describe an effect in which cells that have not been exposed to radiation are affected by irradiated cells though various intracellular signaling mechanisms. In this study we analyzed the kinetics and mechanisms of bystander effect and radioadaptation in embryonic zebrafish cells (ZF4) exposed to chronic low dose of gamma rays. ZF4 cells were irradiated for 4 hours with total doses of gamma irradiation ranging from 0.01-0.1 Gy. In two experimental… CONTINUE READING