Low-Dose Sodium Nitrite Fluid Resuscitation Prevents Lethality From Crush Syndrome by Improving Nitric Oxide Consumption and Preventing Myoglobin Cytotoxicity in Kidney in A Rat Model.

@article{Murata2017LowDoseSN,
  title={Low-Dose Sodium Nitrite Fluid Resuscitation Prevents Lethality From Crush Syndrome by Improving Nitric Oxide Consumption and Preventing Myoglobin Cytotoxicity in Kidney in A Rat Model.},
  author={Isamu Murata and Yumi Miyake and Naomi Takahashi and Ryuta Suzuki and Takayuki Fujiwara and Yuji Sato and Yutaka Inoue and Jun Kobayashi and Ikuo Kanamoto},
  journal={Shock},
  year={2017},
  volume={48 1},
  pages={
          112-118
        }
}
OBJECTIVE Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from pressure. CS has a high mortality, even when patients receive fluid therapy. We examined whether administration of NaNO2-containing fluid can improve survival in a rat model of CS. DESIGN The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into six groups: sham; CS with no… CONTINUE READING
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