Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis

@article{Cronstein2005LowDoseMA,
  title={Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis},
  author={Bruce N. Cronstein},
  journal={Pharmacological Reviews},
  year={2005},
  volume={57},
  pages={163 - 172}
}
Methotrexate administered weekly in low doses is a mainstay in the therapy of rheumatoid arthritis. Although originally developed as a folate antagonist for the treatment of cancer, its mechanism of action in the therapy of rheumatoid arthritis remains less clear. Several mechanisms have been proposed including inhibition of T cell proliferation via its effects on purine and pyrimidine metabolism, inhibition of transmethylation reactions required for the prevention of T cell cytotoxicity… Expand
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TLDR
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