Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis

  title={Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis},
  author={B. Cronstein},
  journal={Pharmacological Reviews},
  pages={163 - 172}
  • B. Cronstein
  • Published 2005
  • Medicine
  • Pharmacological Reviews
  • Methotrexate administered weekly in low doses is a mainstay in the therapy of rheumatoid arthritis. Although originally developed as a folate antagonist for the treatment of cancer, its mechanism of action in the therapy of rheumatoid arthritis remains less clear. Several mechanisms have been proposed including inhibition of T cell proliferation via its effects on purine and pyrimidine metabolism, inhibition of transmethylation reactions required for the prevention of T cell cytotoxicity… CONTINUE READING
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