Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis
@article{Cronstein2005LowDoseMA, title={Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis}, author={B. Cronstein}, journal={Pharmacological Reviews}, year={2005}, volume={57}, pages={163 - 172} }
Methotrexate administered weekly in low doses is a mainstay in the therapy of rheumatoid arthritis. Although originally developed as a folate antagonist for the treatment of cancer, its mechanism of action in the therapy of rheumatoid arthritis remains less clear. Several mechanisms have been proposed including inhibition of T cell proliferation via its effects on purine and pyrimidine metabolism, inhibition of transmethylation reactions required for the prevention of T cell cytotoxicity… CONTINUE READING
Paper Mentions
Interventional Clinical Trial
The aim of the this study is to evaluate the effectiveness of methotrexate added to treatment
as usual on positive and negative symptoms, cognitive and social functioning and quality of… Expand
Conditions | Schizoaffective Disorder, Schizophrenia, Schizophreniform Disorder |
---|---|
Intervention | Drug |
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