Low Dose Influenza Virus Challenge in the Ferret Leads to Increased Virus Shedding and Greater Sensitivity to Oseltamivir

@inproceedings{Marriott2014LowDI,
  title={Low Dose Influenza Virus Challenge in the Ferret Leads to Increased Virus Shedding and Greater Sensitivity to Oseltamivir},
  author={Anthony C. Marriott and Brian K. Dove and Catherine J. Whittaker and Christine Bruce and Kathryn A Ryan and Thomas J H Bean and Emma L Rayner and Geoff Pearson and Irene Taylor and Stuart D Dowall and Jenna Plank and Edmund Newman and Wendy S Barclay and Nigel J. Dimmock and Andrew J Easton and Bassam Hallis and Nigel James Silman and Miles W. Carroll},
  booktitle={PloS one},
  year={2014}
}
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interventions and vaccines. The 2009 pandemic influenza virus (H1N1pdm09) induces mild to moderate respiratory disease in infected ferrets, following inoculation with 106 plaque-forming units (pfu) of virus. We have demonstrated that reducing the challenge… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Induction and relief of nasal congestion in ferrets infected with influenza virus.

International journal of experimental pathology • 1995
View 3 Excerpts
Highly Influenced

Influenza virus aerosol exposure and analytical system for ferrets.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…