Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity

@inproceedings{Veltman2010LowDoseCS,
  title={Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity},
  author={Joris D. Veltman and Margaretha E. H. Lambers and Menno van Nimwegen and Sanne E de Jong and Rudi W Hendriks and Henk C. Hoogsteden and Joachim G. J. V. Aerts and Joost P. J. J. Hegmans},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
Clinical immunotherapy trials like dendritic cell-based vaccinations are hampered by the tumor's offensive repertoire that suppresses the incoming effector cells. Regulatory T cells are instrumental in suppressing the function of cytotoxic T cells. We studied the effect of low-dose cyclophosphamide on the suppressive function of regulatory T cells and investigated if the success rate of dendritic cell immunotherapy could be improved. For this, mesothelioma tumor-bearing mice were treated with… CONTINUE READING
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