Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force

@article{Henderson2014LowDoseAF,
  title={Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force},
  author={Jillian T. Henderson and Evelyn P. Whitlock and Elizabeth A. O’Connor and Caitlyn A. Senger and Jamie H. Thompson and Maya G Rowland},
  journal={Annals of Internal Medicine},
  year={2014},
  volume={160},
  pages={695-703}
}
Preeclampsia is a leading cause of maternal death, affecting 2% to 8% of pregnancies globally (1, 2). It affected 3.8% of U.S. deliveries in 2010, and the rate of severe preeclampsia has increased over the past 3 decades (3). Perinatal mortality is nearly 2 times higher in pregnancies affected by preeclampsia (4), with 12% of maternal deaths due to the condition (5). Serious illness is more common, with more than one third of serious maternal morbidity and 15% of preterm births related to… 
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TLDR
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Aspirin in Preeclampsia: Current Evidence and Future Scope of Research
TLDR
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TLDR
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Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia
Commentary on : Henderson JT, Whitlock EP, O’Connor E, et al. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive
Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement.
TLDR
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Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
TLDR
Daily low-dose aspirin during pregnancy was associated with lower risks of serious perinatal outcomes for individuals at increased risk for preeclampsia, without evident harms.
Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia
TLDR
It is believed that low-dose aspirin therapy should be started at approximately 12 weeks of gestation in agreement with recommendations from other national societies and should not be delayed until the second trimester in women at high risk for adverse placenta-mediated outcomes of pregnancy.
Screening and Prevention of Preeclampsia
TLDR
Traditional method of screening as recommended by professional guidelines has limited predictive performance and therefore should be updated to reflect recent scientific evidence that the target of screening should be preterm PE.
Effect of low dose aspirin on maternal outcome in women at risk for developing pregnancy induced hypertension
TLDR
Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy and can be considered a safe drug without any deleterious side effect for mother and the fetus.
Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia
TLDR
Clinicians may wish to inform patients at high risk of preeclampsia that aspirin prophylaxis has been shown to have the potential for significant health benefits, as there is insufficient evidence to recommend for or against routine aspirin proPHylaxis in pregnancy.
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