Low-Density Lipoprotein Receptor (LDLR) Family Orchestrates Cholesterol Homeostasis

@inproceedings{Go2012LowDensityLR,
  title={Low-Density Lipoprotein Receptor (LDLR) Family Orchestrates
Cholesterol Homeostasis},
  author={Gwang-Woong Go and Arya Mani},
  booktitle={The Yale journal of biology and medicine},
  year={2012}
}
The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in cardiovascular disease has been widely studied, only recently the role of other members of the LDLR proteins in lipoprotein homeostasis and atherosclerosis has emerged. LDLR, VLDLR, and LRPs bind and internalize apoE- and apoB-containing lipoprotein, including LDL and VLDL, and regulate their cellular uptake. LRP6 is a unique member of this family for its function as a co-receptor for Wnt signal… CONTINUE READING

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