Corpus ID: 13495748

Low Density Lipoprotein Binding and Uptake by Human and Rat Islet b Cells

  title={Low Density Lipoprotein Binding and Uptake by Human and Rat Islet b Cells},
  author={A. Grupping and M. Cnop and C. F. Schravendijk and J. C. Hannaert and T. J. C. V. Berkel and D. Pipeleers},
  • A. Grupping, M. Cnop, +3 authors D. Pipeleers
  • Published 1997
  • Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic b cells. This study investigates whether low density lipoproteins (LDL) exhibit specific interactions with islet b cells. Radioactively labeled LDL (I-LDL) and fluorescently labeled LDL (DiI-LDL) were used as tracers. Rat islet cells express high affinity LDL binding sites (Kd 5 9 nM), which are also recognized by very low… CONTINUE READING
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