Low Ca2+ buffering in hypoglossal motoneurons of mutant SOD1 (G93A) mice.

Abstract

Mutations in the Cu/Zn superoxide dismutase (SOD1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by a selective degeneration of brainstem and spinal motoneurons. The pathomechanism of degeneration is still incompletely understood, but includes a disruption in cellular Ca2+ homeostasis. Here we… (More)
DOI: 10.1016/j.neulet.2008.08.084

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