Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children.

@article{Zhang2007LowCT,
  title={Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children.},
  author={Qibo Zhang and Linda Bagrade and Jolanta Bernatoniene and Ed Clarke and James C Paton and Tim J Mitchell and D. A. Nunez and Adam Finn},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 8},
  pages={1194-202}
}
BACKGROUND Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection. METHODS CD4 T cell proliferative responses to the pneumococcal proteins pneumolysin (Ply), Ply toxoid (F433), and choline-binding protein A were investigated in peripheral blood mononuclear cells (PBMCs) and adenoidal mononuclear cells (MNCs) obtained from children undergoing adenoidectomy. RESULTS Ply and F433 induce significant proliferation of CD4 T cells in both PBMCs… CONTINUE READING

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Antibody responses to D ow naded rom http/academ ic.p.com /jid/article-a/195/8/1194/817715 by gest on 24 N ovem er 2018

D Goldblatt, M Hussain, N Andrews
JID • 2007

CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization.

Proceedings of the National Academy of Sciences of the United States of America • 2005

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