Low-Affinity Heparin Stimulates the Inactivation of Plasminogen Activator Inhibitor-l by Thrombin


The influence of heparin on the reaction between thrombin and plasminogen activator inhibitor-l (PAI-1) has been examined. With a 50-fold excess of PAI-1, the rate constant for the inhibition of thrombin was 458 mol/L"s", which increased to 5,000 mol/L"s" in the presence of 25 pg/mL unfractionated heparin or heparin with low affinity for antithrombin. The… (More)


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