Low ADAMTS13 activity is associated with an increased risk of ischemic stroke.

@article{Sonneveld2015LowAA,
  title={Low ADAMTS13 activity is associated with an increased risk of ischemic stroke.},
  author={Michelle Alida Helena Sonneveld and Moniek P M de Maat and Marileen P. Portegies and Maryam Kavousi and Albert Hofman and Peter L Turecek and Hanspeter Rottensteiner and Fritz Scheiflinger and Peter J Koudstaal and M. Arfan Ikram and Frank W G Leebeek},
  journal={Blood},
  year={2015},
  volume={126 25},
  pages={2739-46}
}
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin motif repeats 13) has antithrombotic properties because it cleaves von Willebrand factor (VWF) in smaller, less active multimers. The aim of our study was to investigate prospectively the association between ADAMTS13 activity and ischemic stroke. We included 5941 individuals ≥55 years without a history of stroke or transient ischemic attack (TIA) of the Rotterdam Study, a population-based cohort study. ADAMTS13 activity was… CONTINUE READING
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