Low‐dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial

  title={Low‐dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial},
  author={Cristhine Souza Le{\~a}o Kamamoto and Adriana Sa{\~n}udo and Karime Hassun and Edil{\'e}ia Bagatin},
  journal={International Journal of Dermatology},
The efficacy of low‐dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies. 

Management of patients with seborrheic dermatitis

The data on modern methods of management of patients with severe forms of SD, allowing for a long time to achieve regression of skin rashes and significantly improve the quality of life of the patient, are presented.

Dermatological indications for the use of isotretinoin beyond acne

Isotretinoin, if used within the correct cohort with appropriate pretreatment counseling regarding side-effects, is a well-tolerated medication with potential as either an adjunctive treatment or a second-line agent in those recalcitrant cases unresponsive to first-line therapy.

Seborrheic dermatitis and pityriasis sicca: A review

A concise review of seborrheic dermatitis and pityriasis sicca is presented and it is shown that the former is more common than the latter in the general population.

Efficacy and safety of low dose oral isotretinoin in comparison with oral itraconazole in the treatment of seborrheic dermatitis among patients attending Erbil dermatology teaching center in Erbil City

Low dose oral isotretinoin is more effective than oral itraconazole in treating seborrheic dermatitis, when the two groups were compared, patients taking oral isot retinoin showed a significantly greater decrease in sebor rheopathic dermatitis area severity index score than itraconsolid group particularly in the second and third months of treatment.

Low dose of isotretinoin: A comprehensive review

Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in theField of gastroenterology, and is highlighted on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotRetinoin.

Treatment of seborrheic dermatitis: a comprehensive review

The current knowledge on SD treatment is summarized and appropriate directions for future cases that dermatologists may face are attempted to provide appropriate directions.

Systemic isotretinoin in treatment of severe seborrheic dermatitis

The use of low doses of systemic isotretinoin proved to be an effective method of drug therapy for severe seborrheic dermatitis and demonstrated a distinct improvement in the quality of life of patients.

Features of management of patients with seborrheic dermatitis

In the treatment of persistent and long-term forms of seborrheic dermatitis, systemic antifungal agents and systemic retinoids are used, which allow for a long time to achieve regression of skin rashes and significantly improve the quality of life of the patient.

Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial

Treatment based in antifungal combined to topical keratolitic agents as it reduces the sebum production, glandular's size and possesses anti-inflammatory properties and genotypic identification of Malassezia species before and after low-dose oral isotretinoin or topical antif fungus treatments for moderate to severe seborrhea/seborrheic dermatitis on scalp was indicated.



Comparison of the efficacies of intermittent and continuous low‐dose isotretinoin regimens in the treatment of moderate acne vulgaris

This study aimed to compare the efficacies of intermittent and continuous low‐dose isotretinoin regimens in the treatment of moderate acne vulgaris.

Low dose isotretinoin combined with tretinoin is effective to correct abnormalities of acne

This study results show that low dose oral isotretinoin is effective in the therapy of acne papulopustulosa and acne conglobata when given in combination with topical t retinoin.

Very low dose isotretinoin is effective in controlling seborrhea

Excessive seborrhea, coarse‐pored skin, minimal acne and oily scalp hair comprise a well‐known clinical entity and in women, oral isotretinoin is the most effective remedy, followed by antiandrogens.

Effectiveness of conventional, low‐dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study

This study presents data regarding the efficacy of low‐dose and intermittent isotretinoin treatment in patients with acne, and compares these three therapeutic regimens simultaneously.

Seborrheic dermatitis: an overview.

Topical therapy primarily consists of antifungal agents and low-potency steroids and new topical calcineurin inhibitors (immunomodulators) sometimes are administered.

Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study

Intermittent isotretinoin may represent an effective alternative treatment, especially in moderate acne with a low incidence and severity of side effects, and can be recommended in those patients not tolerating the classical dosage.

Low-dose isotretinoin in the treatment of acne vulgaris.

Systematic Review of Oral Treatments for Seborrheic Dermatitis

The clinical efficacy outcome reported varied considerably between the studies, preventing statistical analysis and direct comparison between treatments, however, ketoconazole therapy was associated with more relapses compared with other treatments.


The anti-inflammatory activity of oral itraconazole suggests that it should be the first-line therapy in severe SD.

Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.

  • C. Zouboulis
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2006
Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism, and was attributed a portion of this decrease to cell cycle arrest and detected sebocyte apoptosis, which was not recapitulated by alit retinoin or tretino in.