Low‐dose combination therapy of DUP‐785 and RS‐61443 prolongs cardiac allograft survival in rats

@article{Bechstein1992LowdoseCT,
  title={Low‐dose combination therapy of DUP‐785 and RS‐61443 prolongs cardiac allograft survival in rats},
  author={W. Bechstein and Y. Suzuki and B. Jaffee and A. Allison and D. Hullett and H. Sollinger},
  journal={Transplant International},
  year={1992},
  volume={5}
}
The introduction of cyclosporine into the immunosuppressive armamentarium has revolutionized transplant surgery with significant improvements in graft survival. The apparent lack of effect of cyclosporine on humoral rejection mechanisms makes the search for other immuno‐suppressive agents desirable. Two anti‐metabolites affecting nucleotide synthesis via different pathways have recently been evaluated for their immunosuppressive potential. DUP‐785 (DUP), also known as brequinar sodium… Expand

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( I 99 I ) Inhibition of both MLC and in vitro IgG memory response tote - tanus toxoid by RS - 61443
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