Low‐calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues

@article{Kroger2006LowcalorieSA,
  title={Low‐calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues},
  author={Manfred Kroger and Kathleen Meister and Ruth Kava},
  journal={Comprehensive Reviews in Food Science and Food Safety},
  year={2006},
  volume={5},
  pages={35-47}
}
Sugar-free or reduced-sugar foods and beverages are very popular in the United States and other countries, and the sweeteners that make them possible are among the most conspicuous ingredients in the food supply. Extensive scientific research has demonstrated the safety of the 5 low-calorie sweeteners currently approved for use in foods in the United States–acesulfame K, aspartame, neotame, saccharin, and sucralose. A controversial animal cancer study of aspartame conducted using unusual… 
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References

SHOWING 1-10 OF 114 REFERENCES
Reported Use of Reduced‐sugar Foods and Beverages Reflect High‐quality Diets
TLDR
Comparisons were made between demographic characteristics, body mass index, food group servings, food intake amounts, and nutrient densities, and RS users consistently reported significantly higher intakes of fruit, lower intakes of discretionary fat and added sugars, and equal orLower intakes of other foods, except for greater intake of yogurt and frozen and gelatin desserts.
Aspartame: scientific evaluation in the postmarketing period.
TLDR
Evaluation of the anecdotal reports of adverse health effects revealed that the reported effects were generally mild and also common in the general population and that there was no consistent or unique pattern of symptoms that could be causally linked to consumption of aspartame.
Aspartame: review of safety.
TLDR
The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive, and there are no unresolved questions regarding its safety under conditions of intended use.
Effects of intense sweeteners on hunger, food intake, and body weight: a review.
  • B. Rolls
  • Medicine
    The American journal of clinical nutrition
  • 1991
TLDR
Preliminary clinical trials suggest that aspartame may be useful aid in a complete diet-and-exercise program or in weight maintenance, and intense sweeteners have never been found to cause weight gain in humans.
Acceptable daily intake vs actual intake: the aspartame example.
TLDR
The acceptable daily intake (ADI) and the postmarketing surveillance of consumption levels for a food additive, using the widely used food additive aspartame (APM, L-aspartyl-L-phenylalanine methyl ester) as an example is discussed.
Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake.
  • J. Rodin
  • Medicine
    The American journal of clinical nutrition
  • 1990
TLDR
When subjects drank the fructose preload, they subsequently ate fewer overall calories and fewer grams of fat than when they drank any of the other preloads, and the aspartame load did not stimulate intake beyond the plain-water control.
Vegetables, fruits and phytoestrogens in the prevention of diseases.
  • D. Heber
  • Medicine
    Journal of postgraduate medicine
  • 2004
TLDR
Consumers are advised to ingest one serving of each of the seven colour groups daily, putting this recommendation within the United States National Cancer Institute and American Institute for Cancer Research guidelines of five to nine servings per day.
Monitoring sweetener consumption in Great Britain.
TLDR
The quantities consumed of all sweeteners were found to be below the Acceptable Daily Intake (ADI) values established by the Joint FAO/WHO Expert Committee on Food Additives, the European Commission Scientific Committee for Food or the UK Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment.
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