Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway.

@article{Shigeto2008LowBP,
  title={Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway.},
  author={Makoto Shigeto and Masashi Katsura and Masafumi Matsuda and Seitaro Ohkuma and Kohei Kaku},
  journal={Journal of pharmacological sciences},
  year={2008},
  volume={108 3},
  pages={274-9}
}
Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations. Alteration of plasma GLP-1 concentration at pM order lowers blood glucose concentration. In this study, we examined the GLP-1 action mechanism at a physiological concentration on insulin secretion. A high concentration of GLP-1 (10 nM) stimulated intracellular… CONTINUE READING
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