Lovastatin treatment inhibits sterol synthesis and induces HMG-CoA reductase activity in mononuclear leukocytes of normal subjects.

@article{Stone1989LovastatinTI,
  title={Lovastatin treatment inhibits sterol synthesis and induces HMG-CoA reductase activity in mononuclear leukocytes of normal subjects.},
  author={Bradford G. Stone and Christopher C D Evans and William F. Prigge and William C. Duane and Roger L. Gebhard},
  journal={Journal of lipid research},
  year={1989},
  volume={30 12},
  pages={1943-52}
}
The mechanism by which competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase decrease serum cholesterol is incompletely understood. The few available data in humans suggest that chronic administration of the competitive inhibitor, lovastatin, decreases serum cholesterol with little or no change in total body sterol synthesis. To further define the effect of lovastatin on cholesterol synthesis in normal subjects, we investigated the effect of a single oral dose of… CONTINUE READING