Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.

@article{Biade1993LovastatinPT,
  title={Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.},
  author={S Biade and Jean Claude Mazi{\`e}re and L. Ferreres Mora and Ren{\'e} Santus and C{\'e}cile Mazi{\`e}re and Martine Auclair and Patrice Morli{\`e}re and Louis Dubertret},
  journal={Photochemistry and photobiology},
  year={1993},
  volume={57 2},
  pages={371-5}
}
A 24 h preculture of HT29-18 human colonic adenocarcinoma cells with the sterol synthesis inhibitor lovastatin at concentrations of 0.1-0.5 microM markedly increased the photocytotoxic effect of photofrin II delivered to cells by low density lipoproteins. Under the same conditions, LDL binding and photofrin II (PII) uptake by HT29 cells increased about 1.8-fold and 1.5-fold, respectively. These results suggest that hydroxymethylglutaryl-coenzyme A reductase inhibitors could be useful for… CONTINUE READING