Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma.

@article{Chiba2008LovastatinIB,
  title={Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma.},
  author={Yoshihiko Chiba and Junko Arima and Hiroyasu Sakai and Miwa Misawa},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={294 4},
  pages={L705-13}
}
Recent studies revealed an importance of a monomeric GTP-binding protein, RhoA, in contraction of bronchial smooth muscle (BSM). RhoA and its downstream have been proposed as a new target for the treatment of airway hyperresponsiveness in asthma. Statins are known to inhibit the functional activation of RhoA via the depletion of geranylgeranylpyrophosphate. To determine the beneficial effects of statins on the airway hyperresponsiveness in allergic bronchial asthma, we investigated the effects… CONTINUE READING