Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.

@article{Won2008LovastatinIA,
  title={Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.},
  author={Je-song Won and Yeong-Bin Im and Mushfiquddin Khan and Miguel Agustin Contreras and Avtar Kaur Singh and Inderjit Singh},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 4},
  pages={1536-49}
}
Previous studies have described that statins (inhibitors of cholesterol and isoprenoid biosynthesis) inhibit the output of amyloid-beta (Abeta) in the animal model and thus decrease risk of Alzheimer's disease. However, their action mechanism(s) in Abeta precursor protein (APP) processing and Abeta generation is not fully understood. In this study, we report that lovastatin treatment reduced Abeta output in cultured hippocampal neurons as a result of reduced APP levels and beta-secretase… CONTINUE READING