Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

@article{Wagner2010LovastatinIV,
  title={Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.},
  author={Robert J. Wagner and Kathleen A. Martin and Richard James Powell and Eva M. Rzucidlo},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={299 1},
  pages={C119-27}
}
It is becoming increasingly clear that cholesterol-independent effects of statins also contribute to the cardioprotective effects, but these mechanisms remain poorly understood. We investigated the effects of lovastatin on vascular smooth muscle phenotype. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin induces vascular smooth muscle cell (VSMC) differentiation. We found that lovastatin also inhibits mTORC1 signaling and that this… CONTINUE READING
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