Lovastatin-induced apoptosis in human melanoma cell lines.

  title={Lovastatin-induced apoptosis in human melanoma cell lines.},
  author={Yiqun G Shellman and Deborah Ribble and Leslie Keng Pearson G. Edward Miller and John Gendall and Kayleen Vanbuskirk and Desiree P Kelly and David A. Norris and Robert P. Dellavalle},
  journal={Melanoma research},
  volume={15 2},
The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell lines was examined by Cell Titer 96 Aqueous One solution cell proliferation assay (MTS assay). Apoptosis was assayed by ethidium bromide and acridine orange morphologic assays, an Annexin V apoptosis… CONTINUE READING


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