Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.

@article{Park2001LovastatininducedEM,
  title={Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.},
  author={Chaehwa Park and I Lee and Won Ki Kang},
  journal={Carcinogenesis},
  year={2001},
  volume={22 10},
  pages={1727-31}
}
Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, induces growth arrest in a variety of cancer cell lines. Its mechanism of action, however, has not been completely elucidated. E2F-1 is thought to act as an oncogene and a tumour suppressor, with its action probably dependent upon the cellular context. We have shown in this study that transcriptional regulation and proteasomal degradation of E2F-1 are critical regulatory events in lovastatin-induced cell death… CONTINUE READING

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