Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii

@inproceedings{Jahromi2013LovastatinIA,
  title={Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii},
  author={Mohammad Faseleh Jahromi and Juan Boo Liang and Yin Wan Ho and Rosfarizan Mohamad and Yong Meng Goh and Parisa Shokryazdan and James Chin},
  booktitle={BioMed research international},
  year={2013}
}
Lovastatin, a natural byproduct of some fungi, is able to inhibit HMG-CoA (3-hydroxy-3 methyl glutaryl CoA) reductase. This is a key enzyme involved in isoprenoid synthesis and essential for cell membrane formation in methanogenic Archaea. In this paper, experiments were designed to test the hypothesis that lovastatin secreted by Aspergillus terreus in fermented rice straw extracts (FRSE) can inhibit growth and CH4 production in Methanobrevibacter smithii (a test methanogen). By HPLC analysis… CONTINUE READING