Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X‐ adrenoleukodystrophy

@article{Singh1998LovastatinAS,
  title={Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X‐ adrenoleukodystrophy},
  author={Inderjit Singh and Kalipada Pahan and M. A. Khan},
  journal={FEBS Letters},
  year={1998},
  volume={426}
}
The present study underlines the importance of lovastatin, an inhibitor of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase, and the sodium salt of phenylacetic acid (NaPA), an inhibitor of mevalonate pyrophosphate decarboxylase, in normalizing the pathognomonic accumulation of saturated very long chain fatty acids (VLCFA) in cultured skin fibroblasts of X‐adrenoleukodystrophy (X‐ALD) in which the ALD gene is either mutated or deleted. Lovastatin or NaPA alone or in combination… Expand
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