Lovastatin Decreases Acute Mucosal Inflammation Via 15-epi-Lipoxin A4

  title={Lovastatin Decreases Acute Mucosal Inflammation Via 15-epi-Lipoxin A4},
  author={Anna Planagum{\`a} and Michael A. Pfeffer and Geoffrey D. Rubin and Roxanne Croze and Mohib Uddin and Charles N Serhan and Bruce David Levy},
  booktitle={Mucosal Immunology},
The widespread use of statins for hypercholesterolemia has uncovered pleiotropic anti-inflammatory properties that were unexpected based on the drugs' original design; yet, mechanisms for these protective actions remain uncertain. In this study lovastatin triggered biosynthesis of the anti-inflammatory and pro-resolving mediator 15-epi-lipoxin A4 (15-epi-LXA4). During interactions between human neutrophils and airway epithelial cells, the statin-induced increase in 15-epi-LXA4 was associated… CONTINUE READING


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