Lotronex and the FDA: a fatal erosion of integrity

  title={Lotronex and the FDA: a fatal erosion of integrity},
  author={Richard C. Horton},
  journal={The Lancet},
  • R. Horton
  • Published 19 May 2001
  • Medicine
  • The Lancet
Review: Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome
  • S. Lucak
  • Medicine
    Therapeutic advances in gastroenterology
  • 2010
Alosetron hydrochloride (Lotronex®), a selective serotonin type 3 receptor antagonist, is the only medication approved for the treatment of severe diarrhea-predominant irritable bowel syndrome in women who have inadequately responded to conventional therapy.
Psychology in the prescription era: building a firewall between marketing and science.
To preserve the integrity of psychological science, the authors propose an aspirational "firewall" designed to separate industry marketing from the science of psychology.
Schizophrenia trials: past, present and future
  • C. Adams
  • Medicine, Psychology
    Epidemiologia e Psichiatria Sociale
  • 2002
It is now over 50 years since the value of streptomycin in tuberculosis was demonstrated in the first randomised trial and this methodology is now seen as the 'gold standard' means by which different forms of mental health care are evaluated.
Response to Black et al.
The will of Congress? Permissive regulation and the strategic use of labeling for the anti-influenza drug Relenza
It is argued that the Relenza case highlights contradictions between a scientific culture at FDA, conducive to rigorous product evaluations, and the agency’s attempts to accommodate higher-level political and industry demands conducive of permissive regulation.
Medical nihilism: The limits of a decontextualised critique of medicine.
  • A. Devanesan
  • Psychology, Philosophy
    Studies in history and philosophy of biological and biomedical sciences
  • 2019
Irritable bowel Syndrome with reference of Alosetron Hydrochloride and Excipient profile used in the manufacturing of Alosetron tablet-A review
This transient audit portrays the historical backdrop of alosetron, effectiveness of alOSetron inside the treatment of IBS, the effect of extreme IBS on HRQoL, wellbeing issues, the possibility investigation and alleviation methodology program underneath that alosETron is as of now endorsed, and a report on post advancing data.
Review of Drug-induced Injury in Mucosal Biopsies From the Tubular Gastrointestinal Tract
A comprehensive overview of the drugs known to cause mucosal injuries in the tubular gastrointestinal tract organized by the organ involved and the prominent pattern of injury is provided.
Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines.
This review summarizes and provides updated literature on heterocyclic compounds using various cancer cell lines reported during the period of 2014-2017 together with the structure-activity relationships.
Biomedical Significance of Tryptamine: A Review
Tryptamine the important psychotropic drug having indole ring has wider biological and pharmaceutical significance as neurotransmitter and neuromodulator, vasoconstrictor and vasodilator, antimicrobial and antibacterial, antioxidant and antifungal agents.