Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum

@article{Tarayre2005Lotifazole1,
  title={Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum},
  author={J. P. Tarayre and V. Caillol and M. Barbara and G. Villanova and M. Bru and M. Aliaga and H. Lauressergues},
  journal={Agents and Actions},
  year={2005},
  volume={14},
  pages={93-101}
}
  • J. P. Tarayre, V. Caillol, +4 authors H. Lauressergues
  • Published 2005
  • Medicine
  • Agents and Actions
  • Lotifazole (F 1686) — 4-phenyl-2-(2′, 2′, 2-trichloroethoxycarboxamido) thiazole — has a range of antiinflammatory activities in animals that differs from the activities of classic non-steroidal drugs. It reduces carrageenin-induced oedema in rats, UV-induced erythema in guinea pigs, and Arthus pleurisies in rats only at high doses. It does not affect Freund's-adjuvant polyarthritis, and it only slightly affects passive skin anaphylaxis in rats and anaphylactic shock in guinea pigs. Lotifazole… CONTINUE READING

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