Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum

  title={Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum},
  author={J. P. Tarayre and V. Caillol and M. Barbara and Gustavo Villanova and M. Bru and M. Aliaga and Henri Lauressergues},
  journal={Agents and Actions},
Lotifazole (F 1686) — 4-phenyl-2-(2′, 2′, 2-trichloroethoxycarboxamido) thiazole — has a range of antiinflammatory activities in animals that differs from the activities of classic non-steroidal drugs. It reduces carrageenin-induced oedema in rats, UV-induced erythema in guinea pigs, and Arthus pleurisies in rats only at high doses. It does not affect Freund's-adjuvant polyarthritis, and it only slightly affects passive skin anaphylaxis in rats and anaphylactic shock in guinea pigs. Lotifazole… 


Comparison of the effect of phenylbutazone, desonide and cyclophosphamide on four types of experimental pleurisy
The action of phenylbutazone, a non‐steroid anti‐inflammatory drug, desonide, a corticosteroid, and cyclophosphamide, an immunosuppressant agent, was studied on four types of experimental pleurisy:
Comparison of the effects of a non-steroidal anti-inflammatory agent, an immunosuppressive, a corticosteroid and an immunomodulator on various immunological and non-immunological inflammatory experimental models.
The effects of a non-steroidal anti-inflammatory agent, phenylbutazone, a corticosteroid, desonide, an immunosuppressive, cyclophosphamide and an immunomodulator, levamisole on a number of
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat.
The authors studied various drugs with anti-inflammatory or antirheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat to find out the action on the volume of pleural exudate and on cell events.
Modification of two models of Arthus reaction in the rat by various drugs.
The action of several steroidal and non-steroidal antiinflammatory agents, immunosuppressives, and antirheumatics was studied in two models of Arthus-passive reaction in the rat: paw oedema induced by an anti-ovalbumin serum, and pleurisy induced by a anti-bovine-albumin serum.
Action of some non-steroid anti-inflammatory drugs on skin anaphylaxis due to ovalbumin in the rat and the guinea pig.
Six non-steroidal anti-inflammatory drugs, metiazinic and niflumic acids, iburofen, indometacin, ketoprofen and phenylbutazone, were tested on two anaphylactic skin reactions to ovalbumin: the
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
  • C. Winter, E. Risley, G. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer.
Ear swelling in mice was measured with a micrometer and used to quantify 24-hour skin reactions to protein antigens and contact sensitivity was readily transferred in inbred mice by peritoneal exudate cells when the challenge was undertaken immediately after transfer.
  • B. Newbould
  • Medicine, Biology
    British journal of pharmacology and chemotherapy
  • 1963
Anti-inflammatory activity was readily observed in certain steroids, pyrazolidines, salicylates and sodium aurothiomalate, and the inhibition obtained by daily treatment with the steroid paramethasone disappeared when treatment was withdrawn.
Experimental pleural effusion as a manifestation of delayed hypersensitivity to tuberculin PPD.
Studies utilizing in vitro incubations of lungs from sensitized donors indicate a role of soluble mediators released during the hypersensitivity reaction in the induction of pleural effusions, and thus suggest the importance of such mediators in in vivo manifestations of delayed hypersensitivity.
Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea-pig in vivo.
Dose-ratio the ratio of equiactive doses of agonist administered after and before the stated dose of antagonist, obtained with the background of treatment used in tests to detect the corresponding agonist in, anaphylactic bronchoconstriction.