Lost in the zygote: the dilution of paternal mtDNA upon fertilization

  title={Lost in the zygote: the dilution of paternal mtDNA upon fertilization},
  author={J. N. Wolff and N. Gemmell},
  • J. N. Wolff, N. Gemmell
  • Published 2008
  • Biology, Medicine
  • Heredity
  • The mechanisms by which paternal inheritance of mitochondrial DNA (mtDNA) (paternal leakage) and, subsequently, recombination of mtDNA are prevented vary in a species-specific manner with one mechanism in common: paternally derived mtDNA is assumed to be vastly outnumbered by maternal mtDNA in the zygote. To date, this dilution effect has only been described for two mammalian species, human and mouse. Here, we estimate the mtDNA content of chinook salmon oocytes to evaluate the dilution effect… CONTINUE READING
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