Lost in spatial translation – A novel tool to objectively assess spatial disorientation in Alzheimer's disease and frontotemporal dementia

@article{Tu2015LostIS,
  title={Lost in spatial translation – A novel tool to objectively assess spatial disorientation in Alzheimer's disease and frontotemporal dementia},
  author={Sicong Tu and Stephanie Wong and John R. Hodges and Muireann Irish and Michael Hornberger},
  journal={Cortex},
  year={2015},
  volume={67},
  pages={83-94}
}
Spatial disorientation is a prominent feature of early Alzheimer's disease (AD) attributed to degeneration of medial temporal and parietal brain regions, including the retrosplenial cortex (RSC). By contrast, frontotemporal dementia (FTD) syndromes show generally intact spatial orientation at presentation. However, currently no clinical tasks are routinely administered to objectively assess spatial orientation in these neurodegenerative conditions. In this study we investigated spatial… CONTINUE READING
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