Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.

@article{Mulugeta2015LostAT,
  title={Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.},
  author={Surafel G Mulugeta and Shin-ichi Nureki and Michael F. Beers},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={309 6},
  pages={L507-25}
}
Dating back nearly 35 years ago to the Witschi hypothesis, epithelial cell dysfunction and abnormal wound healing have reemerged as central concepts in the pathophysiology of idiopathic pulmonary fibrosis (IPF) in adults and in interstitial lung disease in children. Alveolar type 2 (AT2) cells represent a metabolically active compartment in the distal air spaces responsible for pulmonary surfactant biosynthesis and function as a progenitor population required for maintenance of alveolar… CONTINUE READING
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