Losses of gallium in common laboratory ware and ways to minimize them

Abstract

Gallium exists both as a cyclotron-produced gammaemitting isotope 67Ga with a half-life of 3.3 days, and as a positron-emitting isotope 68Ga, available as a Ge/ Ga generator, with a half-life of 68 min. The major clinical use of 67Ga has been for tumour imaging (Waxman 1987; Green and Welch 1989), but new potential applications are emerging (Cordasco et al. 1990). It is anticipated that the relatively inexpensive 68Ge/68Ga generators will increase in popularity in medical establishments as the PET facilities become more widely available. 6SGa has been shown to be useful as a label in PET studies, e.g. in the assessment of regional perfusion (Hnatowich 1976; Green and Welch 1989; Schuster 1989) and in investigations of pulmonary vascular permeability (Mintun et al. 1987; Calandrino et al. 1988; Schuster 1989). Because of its long half-life, the ability to monitor easily its concentration, and the commercial availability of this radiopharmaceutical in the form of a citrate or chloride, 67Ga is convenient for laboratory investigations. It is especially useful during the developmental stages of a new radiopharmaceutical compound or method. In the course of such work, a peculiar inconsistency in the results was observed. This was traced eventually to losses of the isotope in the glass ware (i.e. transfer of radioactivity from the liquid into the glass or the screw top). The purpose of this note is to alert the workers in this field about the extent of the problem and to report on the ways to avoid it. A scintillation detector [NaI(T1) crystal optically coupled to an RCA 8054 phototube, Harshaw Chemical, Solon, Ohio) with a counter (Model 994 Dual Counter/ timer, EG&G Ortec, Oak Ridge, Tenn.) was used to measure the radioactivity. The linearity of the response was confirmed by repeated calibration of the instrument

DOI: 10.1007/BF00181290

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Cite this paper

@article{Gonda1991LossesOG, title={Losses of gallium in common laboratory ware and ways to minimize them}, author={Igor Gonda and David L. Swift}, journal={European Journal of Nuclear Medicine}, year={1991}, volume={18}, pages={511-513} }