Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition.

@article{Xiong2012LossOV,
  title={Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition.},
  author={Min Xiong and Junbo Gong and Youhua Liu and Rong Xiang and Xiaoyue Tan},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 7},
  pages={F1107-15}
}
Both peritubular inflammation and tubular epithelial-to-mesenchymal transition (EMT) are critical events during the pathogenesis of renal fibrosis. However, the relationship between these two processes is unclear. Here, we investigated the potential role of the vitamin D receptor (VDR) in coupling peritubular inflammation and EMT. In a mouse model of unilateral ureteral obstruction (UUO), loss of VDR was observed as early as 1 day after surgery. In cultured proximal tubular epithelial HK-2… CONTINUE READING