Loss of vascular endothelial growth factor a activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation.

@article{Rossiter2004LossOV,
  title={Loss of vascular endothelial growth factor a activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation.},
  author={Heidemarie Rossiter and Caterina Barresi and Johannes Pammer and Michael Rendl and Jody Haigh and Erwin F Wagner and Erwin Tschachler},
  journal={Cancer research},
  year={2004},
  volume={64 10},
  pages={3508-16}
}
The angiogenic cytokine vascular endothelial growth factor (VEGF)-A plays a central role in both wound healing and tumor growth. In the skin, epidermal keratinocytes are a major source of this growth factor. To study the contribution of keratinocyte-derived VEGF-A to these angiogenesis-dependent processes, we generated mice in which this cytokine was inactivated specifically in keratin 5-expressing tissues. The mutant mice were macroscopically normal, and the skin capillary system was well… CONTINUE READING

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Hair cycle-dependent expression of VEGF-splice variants in murine skin suggests key functions in the regulation of perifollicular microvascular remodelling [abstract

  • L Mecklenburg, M Nakamura, H Ellerbrok, DJ Tobin, R. Paus
  • Arch Dermatol Res
  • 2002
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