Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia.

@article{Lu2013LossOV,
  title={Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia.},
  author={Ningxia Lu and Kevin M. Sargent and Debra T. Clopton and William E. Pohlmeier and Vanessa M. Brauer and Renee M. McFee and John S Weber and Napoleone M. A. Ferrara and David W. Silversides and Andrea S. Cupp},
  journal={Endocrinology},
  year={2013},
  volume={154 12},
  pages={4790-802}
}
Vascular endothelial growth factor A (VEGFA) isoform treatment has been demonstrated to alter spermatogonial stem cell homeostasis. Therefore, we generated pDmrt1-Cre;Vegfa(-/-) (knockout, KO) mice by crossing pDmrt1-Cre mice to floxed Vegfa mice to test whether loss of all VEGFA isoforms in Sertoli and germ cells would impair spermatogenesis. When first mated, KO males took 14 days longer to get control females pregnant (P < .02) and tended to take longer for all subsequent parturition… CONTINUE READING
10 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis

  • KC Caires, J de Avila, DJ. McLean
  • 2009
2 Excerpts

Similar Papers

Loading similar papers…