Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.

@article{Fisher2004LossOV,
  title={Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors.},
  author={John Timothy Fisher and Sandra G Vincent and Jes{\'u}s Gomeza and Masahisa Yamada and Juergen Wess},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 6},
  pages={711-3}
}
The presence of multiple muscarinic acetylcholine receptor (mAChR) subtypes in the heart and lung, combined with the lack of mAChR subtype-selective ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation. To determine which of the five mAChRs are responsible for the cholinergic control of heart rate and airway caliber in vivo, we performed experiments on mutant mice lacking… CONTINUE READING

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