Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland.

@article{Jger2010LossOT,
  title={Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland.},
  author={Richard J{\"a}ger and Sabine Schaefer and Mathilde Hau-Liersch and Hubert Schorle},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 3},
  pages={
          1027-33
        }
}
Extensive development of the mammary gland occurs during puberty, when rising levels of ovarian hormones induce the formation of highly proliferative terminal end buds (TEBs) at the tips of mammary ducts. TEBs consist of an outer layer of cap cells and of inner body cells. TEBs invade the adipose stroma and bifurcate while extending the ducts to generate an arborized ductal network. We show that in murine mammary glands transcription factor AP-2gamma is strongly expressed in the cap cell layer… CONTINUE READING

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Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.

  • Developmental dynamics : an official publication of the American Association of Anatomists
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