Loss of thyroid hormone receptor beta is associated with increased progenitor proliferation and NeuroD positive cell number in the adult hippocampus

@article{Kapoor2011LossOT,
  title={Loss of thyroid hormone receptor beta is associated with increased progenitor proliferation and NeuroD positive cell number in the adult hippocampus},
  author={Richa Kapoor and Himanish Ghosh and Kristina Nordstrom and Bj{\"o}rn Vennstr{\"o}m and Vidita A. Vaidya},
  journal={Neuroscience Letters},
  year={2011},
  volume={487},
  pages={199-203}
}
Adult hippocampal neurogenesis is modulated by perturbations in thyroid hormone status; however the role of specific thyroid hormone receptors (TRs) in this process is not completely understood. We show here that loss of the TRβ gene results in a significant increase in the proliferation of adult hippocampal progenitors, without any change in immature neuron number or in the neuronal and glial differentiation of progenitors. Using the mitotic marker 5'-bromo-2-deoxyuridine (BrdU) or the… CONTINUE READING
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