Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.

@article{Zhao2020LossOT,
  title={Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.},
  author={Jintao Zhao and Yuan Qu and Hao Gao and Miao Zhong and Xinming Li and Fang Zhang and Yaxiong Chen and Lu Gan and Guodong Hu and Hong Zhang and Shengxiang Zhang and Jianguo Fang},
  journal={Chemical communications},
  year={2020},
  url={https://api.semanticscholar.org/CorpusID:225082279}
}
With the aid of TP-TRFS, a remarkable decline of the TrxR function was observed in the brain of a mouse model of stroke for the first time, providing a mechanistic link of Trx R dysfunction with stroke.
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13 Citations

Fluorogenic probes for thioredoxin reductase activity

Thioredoxin Reductase as a Pharmacological Target.

Rapid detection of thioredoxin reductase with a fluorescent probe via a Tag-Sec method

A Tag-Sec fluorescent probe is presented that could detect both thioredoxin reductase and selenocysteine with high sensitivity, selectivity, broad pH tolerance and good water solubility and it is hoped that the concept could serve as a useful guide to design probes for detecting Sec-containing proteins and clinical diagnosis.

Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives

This review aims to introduce the progress in the development and application of TrxR fluorescent probes in the past years, and it mainly focuses on analyzing their reaction mechanisms, construction strategies, and potential drawbacks.

Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues.

The TP design strategies that have been attempted by researchers to develop enzyme TP fluorescent sensors that are proving very useful in providing insights for enzyme investigation in the biological system are reviewed.

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

It is shown that 1,2-dithiolane probes are nonspecifically reduced by a range of thiol reductants and are not sensitive to TrxR modulation, thus they are unsuitable as cellular probes for TrXR.

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

It is shown that 1,2-dithiolane probes are nonspecifically reduced by a range of thiol reductants and are not sensitive to TrxR modulation, thus they are unsuitable as cellular probes for TrXR.

Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein

Considering the high mitochondrial density in brain and endothelial cells, it is proposed that the cyclophilin D (CypD)-dependent vascular endothelial cell (VECs) necrosis pathway occurring in the mitochondria is one of the major factors that affects angiogenesis.

Rationally designed lipid droplets-selective two-photon nitric oxide probe for high-fidelity neuroinflammation evaluation

Recent Progress on NIR Fluorescent Probes for Enzymes

The NIR fluorescent probe design strategies that have been attempted by researchers to develop Nir fluorescent sensors of enzymes are reviewed, and these works have provided deep and intuitive insights into the study of enzymes in biological systems.

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