Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.

  title={Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.},
  author={Pankaj Kumar Mandal and Manuela Schneider and Pirkko Koelle and Peter Kuhlencordt and Heidi F{\"o}rster and Heike Beck and Georg W. Bornkamm and Marcus Conrad},
  journal={Cancer research},
  volume={70 22},
Tumor cells generate substantial amounts of reactive oxygen species (ROS), engendering the need to maintain high levels of antioxidants such as thioredoxin (Trx)- and glutathione (GSH)-dependent enzymes. Exacerbating oxidative stress by specifically inhibiting these types of ROS-scavenging enzymes has emerged as a promising chemotherapeutic strategy to kill tumor cells. However, potential redundancies among the various antioxidant systems may constrain this simple approach. Trx1 and thioredoxin… CONTINUE READING


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