Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors

  title={Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors},
  author={Dolores Di Vizio and Letizia Cito and Angelo Boccia and Paolo Chieffi and Luigi Insabato and Guido Pettinato and Maria Letizia Motti and Filippo Schepis and Wanda D'Amico and Fernanda Fabiani and Barbara Tavernise and Salvatore Venuta and Alfredo Fusco and Giuseppe Viglietto},
PTEN/MMAC1/TEP1 (hereafter PTEN) is a tumor suppressor gene (located at 10q23) that is frequently mutated or deleted in sporadic human tumors. PTEN encodes a multifunctional phosphatase, which negatively regulates cell growth, migration and survival via the phosphatidylinositol 3′-kinase/AKT signalling pathway. Accordingly, Pten+/− mice develop various types of tumors including teratocarcinomas and teratomas. We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32… CONTINUE READING
36 Citations
12 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.
Showing 1-10 of 12 references


  • GL Mutter, MC Lin, +5 authors CJ. Eng
  • Cancer Inst., 92, 924–930.
  • 2000
Highly Influential
8 Excerpts


  • D Haas-Kogan, N Shalev, M Wong, G Mills, G Yount, D. Stokoe
  • Biol., 8, 1195–1198.
  • 1998
Highly Influential
5 Excerpts

Trends Biochem

  • BM Marte, J. Downward
  • Sci., 22, 355–358.
  • 1997
Highly Influential
3 Excerpts


  • GH Moe-Behrens, FG Klinger, W Eskild, T Grotmol, TB Haugen, M. De Felici
  • Endocrinol. Dec., 17, 2630–2638.
  • 2003


  • Y Wu, D Dowbenko, MT Pisabarro, L Dillard-Telm, H Koeppen, LA. Lasky
  • Biol. Chem., 276, 21745–21753.
  • 2001


  • XP Zhou, O Gimm, H Hampel, T Niemann, MJ Walker, V. Eng
  • J. Pathol., 157, 1123–1128.
  • 2000


  • K Luukko, A Ylikorkala, M Tiainen, TP. Makela
  • Dev., 83, 187–190.
  • 1999
2 Excerpts


  • K Podsypanina, LH Ellenson, +7 authors R. Parsons
  • Natl. Acad. Sci. USA, 96, 1563–1568.
  • 1999


  • Y. Matsui
  • Pathol. Microbiol. Immunol. Scand., 106, 142–148.
  • 1998
1 Excerpt


  • S Scala, P Bruni, L Lo Muzio, M Mignogna, G Viglietto, A. Fusco
  • J. Oncol., 13, 665–668.
  • 1998
1 Excerpt

Similar Papers

Loading similar papers…