Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

@article{Sturm2006LossOT,
  title={Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma},
  author={Isrid Sturm and Christine Stephan and Bernhard F Gillissen and Reiner Siebert and Martin Janz and Silke Radetzki and Klaus Jung and Stefan A. Loening and Bernd Doerken and Peter Ted Daniel},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={619-627}
}
We report for the first time inactivation of a tissue-specific Bcl-2 homology domain 3 (BH3)-only protein as a common aspect in human cancer. In detail, we show that loss of the BH3-only protein natural born killer (Nbk)/Bcl-2-interacting killer (Bik) is a common feature of clear-cell renal cell carcinoma (RCC). While strong Nbk expression is found in the renal tubuli and the epithelial lining of the glomerula, a consistent loss of Nbk expression was observed in primary RCC tissue and RCC cell… CONTINUE READING
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