Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.

@article{May2005LossOT,
  title={Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.},
  author={Scott R. May and Amir M. Ashique and Mattias Karl{\'e}n and Baolin Wang and Yiguo Shen and Kostantinos Zarbalis and Jeremy Reiter and Johan Ericson and Andrew S. Peterson},
  journal={Developmental biology},
  year={2005},
  volume={287 2},
  pages={378-89}
}
Sonic Hedgehog (Shh) signals are transduced into nuclear ratios of Gli transcriptional activator versus repressor. The initial part of this process is accomplished by Shh acting through Patched (Ptc) to regulate Smoothened (Smo) activity. The mechanisms by which Ptc regulates Smo, and Smo activity is transduced to processing of Gli proteins remain unclear. Recently, a forward genetic approach in mice identified a role for intraflagellar transport (IFT) genes in Shh signal transduction… CONTINUE READING
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